Treatment of Early Acute Nonlymphatic Leukemia with Low Dose Cytosine Arabinoside
W. C. Moloney and D. S. Rosenthal    Hämatol. Bluttransf. Vol 26
Successful induction of remissions in adults with acute non lymphatic leukemia (ANLL) requires the use of high dose aggressive chemotherapy which is not well tolerated by older adults and few remissions are obtained in patients with ANLL secondary to refractory anemia and other disorders (Moloney and Rosenthal, to be published) For years investigators have attempted to discover methods of producing remissions by inducing leukemic cells to differentiate and recently Sachs ( 1978) has pointed out that a number of agents were capable of inducing maturation in leukemic mouse myeloblasts. Among the chemical compounds investigated was cytosine arabinoside (Ara-C) an antimetabolite extensively used in high dosage for treatment of ANLL Based on these experimental findings Baccarani and Tura (1979) treated a patient with refractory anemia and excess myeloblasts in the marrow with a short course of low dose Ara-C and obtained an excellent clinical and hematological improvement with partial bone marrow remission, Encouraged by this report we have treated two patients with early ANIL and seven patients with RDA-ANLL with low dose Ara-C, Observations on these cases and preliminary findings on the effect of low dose Ara-C on leukemic cells cultured in diffusion chambers are presented in this paper.